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KMID : 0378019730160060047
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New Medical Journal
1973 Volume.16 No. 6 p.47 ~ p.56
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Effects of Diphenylhydantoin on the Changes of ATPase Activity and Electrolytes Induced by Local Cerebral Cortex Injury in the Rabbit
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Abstract
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The purpose of this study is to observe the effects of diphenylhydantoin on the changes of ATPase activity and electrolytes resulting from damage of cerebral cortex by subcortical injection of blood in the rabbit.
The experimental results were as follows:
1. ATPase activity of subcellular particle membrane fraction of normal cerebral cortex was increased most markedly when Na+ 50 mM and K+ 5 mM were added in the presence of Mgtt 1. 5 mM and trisATP 1.5 mM.
2. ATPase activity of subcellular particle membrane fraction of normal cerebral cortex was also increased by the existence of diphenylhydantoin, especially in the presence of Na+ and K+ ions.
3. The decreased ATPase activity of damaged cerebral cortex was recovered on the 7th postoperative day.
4. For 3 to 6 hours following subcortical injection of blood, ATPase activity of damaged cerebral cortex was not influenced by the existence of diphenylhydantoin, but increased markedly after 24 hours. However, the ratio of ATPase activity was lower in damaged cerebral cortex than contralateral undamaged cerebral cortex.
5. ´Na´-K+-ATPase activity of subcellular particle membrane fraction of cerebral cortex was markedly increased by subcutaneous injection of diphenylhydantoin in normal and injured rabbits.
6. The increase of water, sodium and chloride contents in the damaged cerebral cortex was markedly reduced by administration of diphenylhydantoin,
7. From these experimental observations, it may be possible to conclude that through promoting the ATPase activity and active transport of cellular sodium ion, the diphenylhydantoin seems to have the effect of reducing cerebral edema in the damaged cerebral cortex.
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